anti-MUC-17 (Mucin-17) (human), Rabbit Monoclonal (RM517)

RevMAb Biosciences

anti-Mucin-17 (human), Rabbit Monoclonal (RM517)

10

ImmunoHistoChemistry

Research Use Only

Monoclonal

RM517

MUC17

mucin 17, cell surface associated

membrane mucin MUC17; MUC-17; MUC3; MUC-3; mucin-17; secreted mucin MUC17; small intestinal mucin MUC3; small intestinal mucin-3

Rabbit

IgG

Mucin-17

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC-17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. MUC-17 interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. MUC-17 probably plays a role in maintaining homeostasis on mucosal surfaces. Increased expression of this molecule has been reported in colon cancer. - Recombinant Antibody. This antibody reacts to human Muc-17 (Mucin-17). Isotype: Rabbit IgG. Immunogen: A peptide corresponding to residues near the C-terminus of human Muc17. Applications: IHC. Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC-17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. MUC-17 interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. MUC-17 probably plays a role in maintaining homeostasis on mucosal surfaces. Increased expression of this molecule has been reported in colon cancer.

-20°C

12352203