Anti-MuSK; [MuSK #13], Mouse IgG2a, Fc Silent(tm), kappa

Absolute Antibody

Anti-MuSK; [MuSK #13], Mouse IgG2a, Fc Silent(tm), kappa

9

This antibody is specific for human MuSK.

The original antibody was used in vitro to test if it could activate its target. It showed to be a potent MuSK activator. The antibody was also tested in vivo on mice. Here is was shown to localize to the neuromuscular junctions here it increased innervation. This antibody did not show any delay in onset of ALS symptoms (Sengupta-Ghosh et al., 2019; PMID:30528255).

Other Application

Research Use Only

Monoclonal

MuSK #13

MUSK

muscle associated receptor tyrosine kinase

CMS9; FADS; FADS1; muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor

Mouse

IgG2a

Muscle, skeletal receptor tyrosine-protein kinase

This is a reformatted mouse IgG2a Fc Silent™ antibody, based on the original mouse IgG2a format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203