Anti-NA, Neuraminidase [NA-45], Human IgG1, Fc Silent(tm), kappa

Absolute Antibody

Anti-NA, Neuraminidase [NA-45], Human IgG1, Fc Silent(tm), kappa

9

This antibody is specific for the active site of neuraminidase from H9 variants of influenza A.

The structure of the original version of this antibody was determined using cryo-EM and x-ray crystallography (Zhu et al., 2020; PMID:31757767, Gilchuk et al., 2019; PMID:31757769). This antibody was used for an ELISA on the NA protein of influenza A. The binding strength of this antibody to neuraminidase of influenza A was determined using surface plasmon resonance. This antibody was used for an egress inhibition assay on MDCK cells infected with influenza A. Here it showed its ability to inhibit egress at low concentrations. This antibody was used for a HDX-MS study. The N9 antigen showed hydrogen-deuterium exchange in the presence of this antibody (Gilchuk et al., 2019; PMID:31757769). This antibody was used for a fetuin-based ELLA NA activity assay. Here it showed inhibition of NA (Zhu et al., 2020; PMID:31757767).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

NA-45

Human

IgG1

Neuraminidase

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human Fab format, created for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203