anti-NCSTN / Nicastrin antibody

Arigo Biolaboratories

anti-NCSTN / Nicastrin antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

NCSTN

nicastrin

anterior pharynx-defective 2; ATAG1874; nicastrin

Rabbit

IgG

This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

Human

-20°C

12352203