Anti N(Epsilon)-(Carboxyethyl) Lysine (CEL) mAb (Clone CEL-SP)

Cosmo Bio USA

Anti N(Epsilon)-(Carboxyethyl) Lysine (CEL) mAb (Clone CEL-SP)

16

Research Use Only

Background Advanced Glycation End Product (AGE) is a general term for structures generated in the late stage of non-enzymatic glycation reactions (Millard reactions) between reducing sugars and proteins. AGE accumulation is known to be significantly elevated in age-related diseases such as diabetes and arteriosclerosis. Nepsilon-(carboxyethyl) lysine (CEL) is generated from protein modification by methylglyoxal (MG). MG is enzymatically derived from the Embden-Meyerhof and polyol pathways, through the degradation of glyceraldehyde-3-phosphate (G3P) (Phillips and Thornalley, 1993). Mclellan et al. (McLellan et al., 1994) demonstrated that plasma MG concentration in insulin-dependent diabetic patients was 7-times higher than in healthy individuals. CEL accumulation increases with age in human lens proteins. Source: Professor Nagai Ryuji, Tokai University Faculty of Agriculture Department of Biosciences Food Bioregulation Research Laboratory Product description References Nagai R., Fujiwara Y., Mera K., Yamagata K., Sakashita N., Takeya M. Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody. J. Immunol. Methods 332, 112-120 (2008). PMID: 18242632

12352203