anti-Neurofilament-L (human), Rabbit Monoclonal (RM280)

RevMAb Biosciences

anti-Neurofilament-L (human), Rabbit Monoclonal (RM280)

10

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM280

NEFL

neurofilament light chain

CMT1F; CMT2E; CMTDIG; light molecular weight neurofilament protein; neurofilament light polypeptide; neurofilament protein, light chain; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament, light polypeptide 68kDa; NF68; NFL; NF-L; PPP1R110; protein phosphatase 1, regulatory subunit 110

Rabbit

IgG

Neurofilament light polypeptide

Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate or 10nm diameter filaments found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit (~70 kDa), NF-M the medium weight microfilament subunit (~160kDa) and NF-H is the heavy or high molecular weight microfilament subunit (~180-220 kDa), with some variation in different species. Antibodies againts the various neurofilament subunits are very useful cell type markers since the proteins are quite abundant and biochemically stable. - Recombinant Antibody. This antibody reacts to human Neurofilament-L (NF-L). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate or 10nm diameter filaments found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit (~70 kDa), NF-M the medium weight microfilament subunit (~160kDa) and NF-H is the heavy or high molecular weight microfilament subunit (~180-220 kDa), with some variation in different species. Antibodies againts the various neurofilament subunits are very useful cell type markers since the proteins are quite abundant and biochemically stable.

-20°C

12352203