Anti-Neurofilament light [MS-C2]

Absolute Antibody

Anti-Neurofilament light [MS-C2]

9

This antibody has been shown to bind to NF-L (neurofilament light) and protocadherin PCDHGC3.

The original human IgG1 version of the recombinant antibody MS-C2 was constructed in order to explore the antigen specificity of the Multiple Sclerosis B cell response (Willis et al, 2015; pmid: 26648933). The antibody was shown to bind two important neural antigens: neurofilament light (NF-L; strong binding with absorbance values that exceeded the mean +2SD of the control data set) and protocadherin PCDHGC3 (Willis et al, 2015; pmid: 26648933). Protocadherin gamma subfamily C, three (PCDHGC3) transcript variant three was of particular interest as a candidate autoantigen as protocadherin isoforms are predominantly expressed in the nervous system and have been implicated in human neurological disorders.

ELISA

Research Use Only

Monoclonal

MS-C2

NEFL

neurofilament light chain

CMT1F; CMT2E; CMTDIG; light molecular weight neurofilament protein; neurofilament light polypeptide; neurofilament protein, light chain; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament, light polypeptide 68kDa; NF68; NFL; NF-L; PPP1R110; protein phosphatase 1, regulatory subunit 110

Human

IgG1

Neurofilament light polypeptide

Human

-20°C,2°C to 8°C

12352203