anti-Notch 1 antibody [mN1A] (PE)
ARG65511
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityMouse
TargetNotch1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Notch 1 antibody [mN1A] (PE)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDmN1A
- Concentration0.1 mg/ml
- ConjugateRPE
- Gene ID18128
- Target nameNotch1
- Target descriptionnotch 1
- Target synonyms9930111A19Rik; lin; lin-12; major type A protein; Mi; Mis6; Motch A; mT14; N; N1; neurogenic locus notch homolog protein 1; Notch gene homolog 1; p300; Ta; Tan1
- HostMouse
- IsotypeIgG1
- Scientific DescriptionNotch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands, such as Delta 1, Jagged1 (CD339), and Jagged2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in brain, lung and thymus.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203