Anti-osteosarcoma-associated cell membrane antigen [TP-3]

Absolute Antibody

Anti-osteosarcoma-associated cell membrane antigen [TP-3]

9

This osteosarcoma-specific antibody binds an epitope on an alkaline phosphatase isoform expressed on both canine and human osteosarcoma cells, but with very limited expression on normal cells and other cancer forms. It also reacts with some other major su

In indirect immunofluorescence assays, this antibody has been show to bind to the surface of human osteosarcoma TPX cells, but not to autologous skin fibroblasts, non-sarcomatous tumor cells or peripheral blood lymphocytes (Bruland et al, 1986).In IHC analysis, this antibody has been shown to bind to osteosarcomas, along with other major human sarcoma subtypes, including synovial sarcomas, malignant fibrous histiocytomas, malignant hemangiopericytomas and chondrosarcomas. It does not react with liposarcomas and leio- and rhabdomyosarcomas, or non-sarcomatous malignancies or normal tissue (Bruland et al, 1986). This binding profile matches that of MAb TP-1. A radiolabelled version of this antibody localises to human osteogenic sarcoma xenografts after intravenous injection (Bruland et al, 1987).

ImmunoFluorescence, ImmunoHistoChemistry

Research Use Only

Monoclonal

TP-3

Human

IgG4

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Canine, Human

-20°C,2°C to 8°C

12352203