Anti-p53 [70237-85]

Absolute Antibody

Anti-p53 [70237-85]

9

This antibody bind p53. It acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively

This antibody is highly similar to the commercially available anti-p53 antibody DO-7. The binding specificity and affinity of this antibody for human p53 was detected using ELISA. The original IgG2a version of this antibody binds p53 with a binding affinity constant of 3.02 X 10^9 M^(-1). Western blotting experiments carried out with this antibody show that it can specifically recognize recombinant p53 protein and Jurkat cell line expressing P53 protein. This antibody can also be used in the detection of p53 in a variety of cancerous tissues including esophageal squamous cell carcinoma, gastric adenocarcinoma, intestinal adenocarcinoma, cervical squamous cell carcinoma, hemangioma, and fibrosarcoma. This antibody was also used in the immunohistochemical analysis of p53 in ovarian serous papillary carcinoma tissue (CN105112377).

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

70237-85

TP53

tumor protein p53

antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; tumor supressor p53

Rabbit

IgG

Cellular tumor antigen p53

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203