Anti-Parathyroid Hormone-related Protein [23-57-137-1]

Absolute Antibody

Anti-Parathyroid Hormone-related Protein [23-57-137-1]

7

The antibody blocks the binding of PTHrP to parathyroid hormone receptor 1 through binding to a site closely overlapping with the receptor-interacting site at the extracellular loop and juxtamembrane regions. The antibody does not block the action of parathyroid hormone (PTH) through the same receptor. The antibody inhibits the action of PTHrP-(1-34) in promoting cAMP production by osteosarcoma cells by 90%,. The antibody also functions in vivo, and can treat nude mice rendered hypercalcemic by PAN-7-JCK cells, and prevents cachexia in mice bearing the LC6-JCK human lung cancer xenograft, independent of the calcium-lowering effect of the antibody. The fab fragment of this antibody, generated by papain digestion, has been used for cystallization of PTHrP at atomic level resolution.

Neutralisation/Blocking, Other Application

neutralize; crystallize

Research Use Only

Parathyroid hormone-related protein

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203