anti-PCNA antibody
ARG54142
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetPCNA
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-PCNA antibody
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- ConjugateUnconjugated
- Gene ID5111
- Target namePCNA
- Target descriptionproliferating cell nuclear antigen
- Target synonymsATLD2; cyclin; DNA polymerase delta auxiliary protein; proliferating cell nuclear antigen
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionAuxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerases processibility during elongation of the leading strand.Induces a robust stimulatory effect on the 3-5 exonuclease and 3-phosphodiesterase,but not apurinic-apyrimidinic (AP) endonuclease,APEX2 activities.Has to be loaded onto DNA in order to be able to stimulate APEX2.Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair:Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases,while Lys-63-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203