Anti-PD-1 [5C4.B8 (Nivolumab)]
Ab00791-15.0
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
Overview
- SupplierAbsolute Antibody
- Product NameAnti-PD-1 [5C4.B8 (Nivolumab)]
- Delivery Days Customer7
- ApplicationsImmunoHistoChemistry
- Applications SupplierIHC; FC; SPR; block
- CertificationResearch Use Only
- Clone ID5C4.B8 (Nivolumab)
- HostHuman
- IsotypeIgM
- ReactivityHuman
- Reactivity SupplierHuman, cynomolgus
- Reactivity Supplier NotemAb PD1.5 was prepared by immunizing IgH and IgK knock-out transgenic mice possessing a human immunoglobulin (heavy chain) minilocus with recombinant human PD-1-Fc protein consisting of the extracellular domain of PD-1 (amino acids 1–167) and the Fc portion of human IgG1, and Chinese hamster ovary (CHO) cells expressing human PD-1. Nivolumab was generated by grafting the variable regions of PD1.5 onto human kappa and IgG4 constant regions containing an S228P mutation (prevents Fab arm exchange with endogenous IgG4 antibodies).
- Storage InstructionStore at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
- UNSPSC12352203