Anti-PD-L2 [TY25]

Absolute Antibody

Anti-PD-L2 [TY25]

9

This antibody binds to mouse PD-L2 and competes with PD-1 binding. It does not cross-react with PD-L1.

This antibody has been used to detect murine PD-L2 by flow cytometry on stimulated dendritic cells as well as various mouse tumour cells. It also detects immunoprecipitates mouse PD-L2 and can be used to detect it by non-reducing Western Blot. TY25 inhibits PD-L2 binding to PD-1 transfected cells (Ansari et al. 2003, PMID: 12847137) and thereby blocks PD-L2 : PD-1 signalling.

Flow Cytometry, ImmunoPrecipitation, Western Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

TY25

Pdcd1lg2

programmed cell death 1 ligand 2

B7-DC; Btdc; butyrophilin B7-DC; butyrophilin-like protein; F730015O22Rik; PD-; PD-1 ligand 2; PDCD1 ligand 2; PD-L2; programmed cell death 1 ligand 2; programmed death ligand 2

Mouse

IgG2a

Programmed cell death 1 ligand 2

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Mouse

12352203