Anti-PDK1 Rabbit mAb

PTM BIO

Anti-PDK1 Rabbit mAb

5

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

IHC-P, ICC/IF

Antibody

Research Use Only

Monoclonal

JRMR-249

Unconjugated

Rabbit

IgG

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via Phosphorylatedrylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203