anti-Perforin antibody [B-D48] (PE)
ARG23364
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetPRF1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Perforin antibody [B-D48] (PE)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDB-D48
- ConjugateRPE
- Gene ID5551
- Target namePRF1
- Target descriptionperforin 1
- Target synonymscytolysin; HPLH2; lymphocyte pore-forming protein; P1; perforin 1 (pore forming protein); perforin-1; PFP
- HostMouse
- IsotypeIgG1
- Scientific DescriptionPerforin with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203