Anti-Phospho-Tau [pT231/pS235_1]

Absolute Antibody

Anti-Phospho-Tau [pT231/pS235_1]

7

This antibody shows binding affinity towards pT231/pS235 peptide of the human tau protein. The binding affinity and specificity of this antibody relied heavily on the phosphorylation at Thr-231.

ELISA was used for the screening of positive clones that bind phosphopeptides. The binding affinity of the IgG antibody towards pT231/pS235 phosphopeptide was found to be Kd = 0.35 nM using surface plasmon resonance. This antibody can recognize the phospho-tau epitopes in full-length human tau. This antibody was also used for the immunohistochemical analysis of the human brain with Alzheimers disease (PMID: 23148212).

ELISA, ImmunoHistoChemistry, Other Application

ELISA; SPR; IHC;

Research Use Only

Monoclonal

pT231/pS235_1

MAPT

microtubule associated protein tau

DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40

Human

IgG1

Microtubule-associated protein tau

This chimeric human antibody was made using the variable domain sequences of the original Chicken scFv format for improved compatibility with existing reagents, assays, and techniques.

Human

-20°C,2°C to 8°C

12352203