Anti-Phosphorylated-BRD2 (Ser37) Rabbit mAb

PTM BIO

Anti-Phosphorylated-BRD2 (Ser37) Rabbit mAb

5

Western Blot

WB

Antibody

Research Use Only

Monoclonal

JMMR-2612

Unconjugated

Rabbit

IgG

Bromodomain-containing protein 2

Brd2 is a highly conserved member of the BET subfamily of bromodomain proteins that contain two tandem N-terminal bromodomains and a single C-terminal extra-terminal (ET) domain. In addition to its involvement in guiding the expression of cell cycle genes through its binding to multiple E2Fs, Brd2 has been shown to be associated with several regulators of transcription, including TFIID and Swi/Snf complexes. First identified as a nuclear serine/threonine kinase, Brd2, like other bromodomain proteins, is thought to function in mammalian development by regulating chromatin structure and transcription. Brd2 has been shown to bind to histone H4 via acetylated Lys12, a substrate of several histone acetyltransferase transcriptional coactivators.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203