Anti-Plasma cell antigen 1 [4G6]

Absolute Antibody

Anti-Plasma cell antigen 1 [4G6]

7

The antibody binds specifically to PC.1, an antigen which is highly expressed on the surface of plasma cells and some non-lymphoid tissue. The antigen is involved with secretion or exocytosis of immunoglobulins from B cells, and may play a role in the secretion of lymphokines from lpr/lpr T cells. When the population of this subset of T cells expands, it accumulates in lymph nodes and results lymphadenopathy. Studies have shown that preventing this expansion by performing neonatal thymectomy delays the onset of systemic lupus erythematosus (SLE), suggesting that the T cells play a role in the development of the autoimmune disease. Monoclonal antibodies directed against PC.1 can be useful in the diagnosis and monitoring of SLE.

Flow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

This chimeric mouse antibody was made using the variable domain sequences of the original Rat format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203