anti-PLK1 phospho (Ser482 / Ser486 / Ser490) antibody

Arigo Biolaboratories

anti-PLK1 phospho (Ser482 / Ser486 / Ser490) antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

plk1.S

polo like kinase 1 S homeolog

plk; plk1; PLK-1; plx1; polo-like kinase 1; serine/threonine-protein kinase PLK1; XELAEV_18047692mg

Rabbit

IgG

Phosphorylated

Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.

Human, Mouse, Rat, Xenopus, Zebra Fish

-20°C

12352203