anti-POLK / DNA Polymerase Kappa antibody

Arigo Biolaboratories

anti-POLK / DNA Polymerase Kappa antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

POLK

DNA polymerase kappa

DINB1; DINP; DNA polymerase kappa; POLQ; polymerase (DNA directed) kappa

Rabbit

IgG

External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010]

Human

-20°C

12352203