Anti-polymorphic epithelial mucin [CTM01]

Absolute Antibody

Anti-polymorphic epithelial mucin [CTM01]

7

This antibody is specific for the glycoprotein polymorphic epithelial mucin (MUC1), expression of which is elevated in a broad range of solid tumours of epithelial origin.

The binding specificity of this antibody for HMFGM has been confirmed in ELISA analysis (Aboud-Pirak et al, 1988). Once bound to its antigen on the plasma membrane of human breast carcinoma MCF-7, this antibody is rapidly endocytosed and delivered to lysosomes for digestion, as established in radiolabelling and fractionation studies (Aboud-Pirak et al, 1988). An 111lndium-labeled human-engineered form of this antibody has been shown to be a suitable carrier for cytotoxic agents in ovarian carcinoma patients (van Hof et al, 1996). Equally, when conjugated to calicheamicin amide, this antibody can target the antitumor antibiotic into MUC1-positive solid tumors (Hamann et al, 2005).

ImmunoPrecipitation, ImmunoHistoChemistry

IP; IHC; therapeutic

Research Use Only

Monoclonal

CTM01

MUC1

mucin 1, cell surface associated

ADMCKD; ADMCKD1; ADTKD2; breast carcinoma-associated antigen DF3; CA 15-3; cancer antigen 15-3; carcinoma-associated mucin; CD227; EMA; episialin; H23 antigen; H23AG; KL-6; krebs von den Lungen-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; mucin 1, transmembrane; mucin-1; peanut-reactive urinary mucin; PEM; PEMT; polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen

Human

IgG1

Mucin-1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG21 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising mice with human milk fat globule membrane

-20°C,2°C to 8°C

12352203