Anti-PPM1D Alexa Fluor(r) 647

EXBIO

Anti-PPM1D Alexa Fluor(r) 647

7

The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D, a protein phosphatase, which contributes to development of some carcinomas.

Flow cytometry: Recommended dilution: 1-5 microg/ml. Intracellular staining.

Flow Cytometry, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

7E11/C5

0.1 mg/ml

AlexaFluor 647

IgG1

PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.

Human, Mouse

2°C to 8°C

12352203