anti-Presenilin 1 / PS1 (CTF) antibody
ARG43010
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetPSEN1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Presenilin 1 / PS1 (CTF) antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5663
- Target namePSEN1
- Target descriptionpresenilin 1
- Target synonymsACNINV3; AD3; FAD; presenilin-1; PS1; PS-1; S182
- HostRabbit
- IsotypeIgG
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203