Anti-Prion [3F4]

Absolute Antibody

Anti-Prion [3F4]

7

The antibody binds specifically to prion, a misfolded protein that has the ability to enter healthy organisms and cause other misfolding of other proteins into their prion form. This plays an essential role in the pathogenesis of certain neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Staussler syndrome (GSS) and bovine spongiform encephalopathy (BSE). These disorders are characterised by an accumulation of prion proteins in the brain, which have a disrupted secondary structure.

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry

ELISA; WB; IHC; IP

Research Use Only

Monoclonal

3F4

Human

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Hamster, Human

Hamster, Human

Hamster 263K PrPs.

-20°C,2°C to 8°C

12352203