Anti-Propionyl-Histone H2A (Lys125) Rabbit mAb

PTM BIO

Anti-Propionyl-Histone H2A (Lys125) Rabbit mAb

5

Anti-Propionyl-Histone H2A (Lys125) Rabbit mAb detects histone H2A only when it is propionylated at Lys125, but not the crotonylated and unmodified H2A peptide at Lys125.

Western Blot, ChIP Chromatin ImmunoPrecipitation

WB, ChIP

Antibody

Research Use Only

Monoclonal

PA-076-08

Unconjugated

Rabbit

IgG

Histone H2A type 1-B/E

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Lysine propionylation (Kprop) is structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. Lysine propionylation is abundant in both prokaryotes and eukaryotes and has been found in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histone H3 at Lys12, propionylation of histone H2A at Lys125 may play a vital role in the epigenetic modulation, including chromatin remodeling and transcriptional regulation.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203