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ProductsBack/Anti-Propionyl-Histone H3 (Lys23) Rabbit pAb

Anti-Propionyl-Histone H3 (Lys23) Rabbit pAb

PTM-205
PTM BIO
ApplicationsWestern Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Propionyl-Histone H3 (Lys23) Rabbit pAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Propionyl-Histone H3 (Lys23) Rabbit pAb detects histone H3 only when it is propionylated at Lys23.
  • Applications
    Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    WB, IHC-P, ChIP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP68431
  • Protein Name
    Histone H3.1
  • Scientific Description
    Histones are subject to a variety of enzyme-catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, and others. Among these modifications, lysine propionylation (Kpr) has emerged as a newly identified reversible modification that plays a crucial role in controlling protein activity. Structurally similar to lysine acetylation, lysine propionylation is prevalent in both prokaryotes and eukaryotes and has been identified in a wide range of proteins, including histones and non-histone substrates like p53. Recent research has unveiled the involvement of stoichiometric complexes comprising lysine acetyltransferase 6A (KAT6A), KAT6B, and bromodomain- and PHD finger-containing protein 1 (BRPF1) in the catalysis of histone H3 Lys23 propionylation (H3K23pr). Importantly, deficiencies in histone propionylation have been associated with developmental disorders and cancer.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein A and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Kezhi Yan, et al. 'Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer' Science Advances (2020)
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  • Jo Chanhee, et al. 'Histone acylation marks respond to metabolic perturbations and enable cellular adaptation' EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
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