Anti-Propionyl-Histone H4 (Lys12) Mouse mAb

PTM BIO

Anti-Propionyl-Histone H4 (Lys12) Mouse mAb

5

Anti-Propionyl-Histone H4 (Lys12) Mouse mAb detects histone H4 only when it is propionylated at Lys12. This antibody has been shown to selectively recognize acetylated H4 peptide at Lys12, but not the structurally similar acetylated, butyrylated, crotonylated peptide at Lys12 or unmodified peptide.

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Antibody

Research Use Only

Monoclonal

Unconjugated

Mouse

IgG

Histone H4

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Lysine propionylation (Kpr), structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. Lysine propionylation is abundant in both prokaryotes and eukaryotes and has been found in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histone H3 at Lys12, propionylation of histone H4 at Lys12 may play a vital role in the epigenetic modulation, includingchromatin remodeling and transcriptional regulation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein G and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203