Anti-Protein C [IgG1-7]

Absolute Antibody

Anti-Protein C [IgG1-7]

9

This antibody specifically recognizes and binds the ProC epitope tag comprising the amino acid sequence EDQVDPRLIDGK. This antibody binds the zymogen form of human Protein C in the activation peptide (spanning the thrombin cleavage site) and blocks protei

This antibody is the humanized version of anti-Protein C antibody HPC-4. The binding of this antibody to protein C is calcium dependent. This humanized anti-protein C antibody exhibited calcium dependent binding which was significantly increased over that of the murine antibody HPC-4. The binding characterization of this antibody was performed using ELISA (PMID: 9680194). This antibody can be used to purify protein tagged with this EDQVDPRLIDGK epitope.

ELISA, Neutralisation/Blocking, Purification/Extraction/Isolation

Research Use Only

Monoclonal

IgG1-7

PROC

protein C, inactivator of coagulation factors Va and VIIIa

activated protein C; anticoagulant protein C; APC; autoprothrombin IIA; blood coagulation factor XIV; PC; prepro-protein C; PROC1; Protein C-Nagoya; THPH3; THPH4; type I protein C; vitamin K-dependent protein C

Rabbit

IgG

Vitamin K-dependent protein C

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203