Anti-PrP [P-clone]

Absolute Antibody

Anti-PrP [P-clone]

9

This antibody binds amino acid residues 90-120 [ amino acids HG(S,N)QWNKPSKPKTN] or epitope I of the bovine prion protein. This epitope is also present in human PrP as well as in all ungulate PrP sequences, including cattle, deer, elk, kudu, goat, and she

Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative prion disease affecting cattle that is transmissible to humans, manifesting as a variant of Creutzfeldt-Jakob disease (vCJD) likely following the consumption of meat contaminated with BSE prions. This high affinity antibody can be used for detection of infectious prion in a sample. P clone has been used in the development of conformation dependent immunoassay for detection of prion protein in a sample. It can recognise prions from cow, sheep, human, deer, hamster in a western blot assay (PMID:12389035). P clone binds peptide derived from the unstructured region (aa90-105) of bovine PrP (BoPrP) with an affinity of 1pM (PMID: 16962610).

Western Blot, ELISA

Research Use Only

Monoclonal

P-clone

PRNP

prion protein

alternative prion protein; AltPrP; major prion protein; major scrapie-associated fibril protein 1; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prn; PrP

Mouse

IgG2b

Major prion protein

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.

Bovine, Deer, Hamster, Human, Mouse, Sheep

-20°C,2°C to 8°C

12352203