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anti-PSD95 antibody [6G6] (AP)

ARG20547
Arigo Biolaboratories
ApplicationsImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityRat
TargetDlg4
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-PSD95 antibody [6G6] (AP)
  • Delivery Days Customer
    23
  • Applications
    ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    6G6
  • Concentration
    1 mg/ml
  • Conjugate
    Alk. Phosphatase
  • Gene ID29495
  • Target name
    Dlg4
  • Target description
    discs large MAGUK scaffold protein 4
  • Target synonyms
    discs, large homolog 4; disks large homolog 4; Dlgh4; postsynaptic density protein 95; PSD95; PSD-95; Sap90; SAP-90; synapse-associated protein 90; synapse-associated protein SAP90
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex. These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins. Thus different PDZ domains of PSD-95 might be specialized for distinct functions. PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism.
  • Reactivity
    Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203