Anti-PSD95 Mouse mAb

PTM BIO

Anti-PSD95 Mouse mAb

5

Western Blot

WB

Antibody

Research Use Only

Monoclonal

11449

Unconjugated

Mouse

IgG

Disks large homolog 4

Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.

Stable for 12 months from date of receipt/reconstitution.

Mouse

Mouse

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203