anti-Raf1 phospho (Ser642) antibody

Arigo Biolaboratories

anti-Raf1 phospho (Ser642) antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

Raf1

Raf-1 proto-oncogene, serine/threonine kinase

cRaf; C-RAF; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); proto-oncogene c-RAF; RAF proto-oncogene serine/threonine-protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-leukemia viral oncogene 1

Rabbit

IgG

Phosphorylated

The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK (Marshall, 1996). Previous studies have shown that phosphorylation is required for Raf-1 activation (Dhillon and Kolch, 2002; Chong et al., 2003). Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf (Dougherty et al., 2005) with two sites participating: Ser301 and Ser642.

Bovine, Canine, Chicken, Human, Mouse, Primate, Rat

-20°C

12352203