Anti-RANK-L [14F3]

Absolute Antibody

Anti-RANK-L [14F3]

9

The antibody is specific for human-RANK-L. It does not recognize murine RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as

The specificity of the original version of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The antibody specifically inhibits the functional activity of RANKL induction of DC maturation. The antibody could strongly inhibit the interaction between human RANKL and its receptor RANK in human monocytes. The inhibition led to antagonism of RANKL-mediated DC maturation and osteoclast development and function (US20040213788).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

14F3

TNFSF11

TNF superfamily member 11

CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11

Human

IgG1

Tumor necrosis factor ligand superfamily member 11

Human

-20°C,2°C to 8°C

12352203