Anti-RANK-L [2A4]

Absolute Antibody

Anti-RANK-L [2A4]

9

The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor related protein that binds to, and activates, the TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differe

The specificity of the original format of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The original format of the antibody blocked the maturation of cells treated with sRANKL, the antibody specifically inhibits the functional activity of RANKL induction of dendritic cells maturation. The original format of the antibody promoted the inhibition of human sRANKL-stimulated bone marrow murine osteoclastogenesis in cell culture. These results showed that the original format of the antibody is a potent inhibitor of the interaction between human RANKL and its receptor RANK (US20030215450A1).

ELISA

Research Use Only

Monoclonal

2A4

TNFSF11

TNF superfamily member 11

CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11

Mouse

IgG2a

Tumor necrosis factor ligand superfamily member 11

Human

-20°C,2°C to 8°C

12352203