Anti-RANK-L [3K7F5]

Absolute Antibody

Anti-RANK-L [3K7F5]

9

The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor related protein that binds to, and activates, the TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differe

The affinity of the original format of the antibody is 0.17x 10-12 nM, as measured by PAE technology. RAW264.7, a murine macrophage cell line that can be induced by RANKL to differentiate into osteoclast-like cells, was used in a TRAP test. In the TRAP test, the original antibody or the Fab fragment were able to neutralize the stimulating effect of RANKL on osteoclast formation from a RAW 264.7 culture. Further, the addition of the original format of the antibody or the Fab fragment inhibited osteoclast differentiation of the RAW cell in a dose-dependent manner. The affinity of the original format and the Fab fragment of the antibody was measured by the Scatchard method (affinity = 8.7 and 6.5 pM). The original antibody and the Fab fragment could significantly increase the bone densities and bone calcium content in a dose-dependent manner, in in vivo experiments (WO2011116527A1).

Other Application

Research Use Only

Monoclonal

3K7F5

TNFSF11

TNF superfamily member 11

CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11

Rabbit

IgG

Tumor necrosis factor ligand superfamily member 11

Human

-20°C,2°C to 8°C

12352203