Anti-RANK-L [WBP114_7.80]

Absolute Antibody

Anti-RANK-L [WBP114_7.80]

9

The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor related protein that binds to, and activates, the TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differe

The specificity of the original format of the antibody to human RANKL was confirmed by ELISA analysis (EC50= 0.12 nM). The antibody could block the RANKL binding to RANK (IC50 = 0.22 nM). The original format of the antibody could inhibit the RANKL-inducible luciferase activity (IC50 = 1.04 nM). The binding affinity of the original format of the antibody to RANKL was measured by surface plasmon resonance (Kd= 60 pM) (WO2019080909).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

WBP114_7.80

TNFSF11

TNF superfamily member 11

CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11

Human

IgG1

Tumor necrosis factor ligand superfamily member 11

Human

-20°C,2°C to 8°C

12352203