anti-RNASEH2B (human), Rabbit Monoclonal (RM433)

RevMAb Biosciences

anti-RNASEH2B (human), Rabbit Monoclonal (RM433)

5

RM433 reacts to human RNASEH2B.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM433

Liquid

RNASEH2B

ribonuclease H2 subunit B

AGS2; Aicardi-Goutieres syndrome 2 protein; deleted in lymphocytic leukemia 8; DLEU8; ribonuclease H2 subunit B; ribonuclease HI subunit B; RNase H2 subunit B

Rabbit

IgG

Ribonuclease H2 subunit B

Recombinant Antibody. This antibody RM433 reacts to human RNASEH2B. Application: IHC, WB . Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection. - RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.

Human

-20°C,2°C to 8°C

12352203