Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissue sections using anti-RNASEH2B antibody (RM433) at 1:100 dilution.,Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue sections using anti-RNASEH2B antibody (RM433) at 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissue sections using anti-RNASEH2B antibody (RM433) at 1:100 dilution.,Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue sections using anti-RNASEH2B antibody (RM433) at 1:100 dilution.
anti-RNASEH2B (human), Rabbit Monoclonal (RM433)
REV-31-1321-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetRNASEH2B
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-RNASEH2B (human), Rabbit Monoclonal (RM433)
- Delivery Days Customer5
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM433
- Gene ID79621
- Target nameRNASEH2B
- Target descriptionribonuclease H2 subunit B
- Target synonymsAGS2; Aicardi-Goutieres syndrome 2 protein; deleted in lymphocytic leukemia 8; DLEU8; ribonuclease H2 subunit B; ribonuclease HI subunit B; RNase H2 subunit B
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRecombinant Antibody. This antibody RM433 reacts to human RNASEH2B. Application: IHC, WB . Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection. - RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203