anti-RNF34 / RFI antibody

Arigo Biolaboratories

anti-RNF34 / RFI antibody

23

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

RNF34

ring finger protein 34

CARP1; CARP-1; caspase regulator CARP1; caspases-8 and -10-associated RING finger protein 1; E3 ubiquitin-protein ligase RNF34; FYVE-RING finger protein MOMO; hRFI; human RING finger homologous to inhibitor of apoptosis protein; RFI; RIF; RIFF; ring finger protein 34, E3 ubiquitin protein ligase; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34

Goat

IgG

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Bovine, Canine, Human, Mouse, Rat

-20°C

12352203