Anti-ROR1 [M508]

Absolute Antibody

Anti-ROR1 [M508]

9

This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis a

The binding reactivity of this antibody to full-length extracellular portion of human ROR1 protein and its truncated forms was done using ELISA. The binding reactivity and specificity of this antibody was comparable with another anti-ROR1 antibody R12. The mouse-human chimeric IgG1 version of this antibody binds human ROR1 with a binding affinity of Kd= 1.4 nM. This antibody could bind human ROR1 expressed on the surface of breast cancer cell line MDA-MB-231 in a flow cytometric assay. This antibody is recommended for detection of human ROR1 expressing tumor cells (CN114539411).

Functional Assay, Flow Cytometry, ELISA

Research Use Only

Monoclonal

M508

ROR1

receptor tyrosine kinase like orphan receptor 1

dJ537F10.1; inactive tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1; NTRKR1

Rabbit

IgG

Inactive tyrosine-protein kinase transmembrane receptor ROR1

Human

-20°C,2°C to 8°C

12352203