Anti-Rotavirus [2B10 (ARP1; VHH1)]

Absolute Antibody

Anti-Rotavirus [2B10 (ARP1; VHH1)]

9

This antibody binds antigens expressed on rotavirus particles. Rotaviruses are the most common cause of infantile diarrhea in the world and most children get infected during the first 5 years of life.

This antibody is capable of binding rotavirus particles present in serum samples in an ELISA. This antibody was capable of reducing the morbidity of rotavirus induced diarrhea in vivo in mice (PMID: 16616802). This antibody is capable of neutralizing rotavirus in vitro and in vivo (PMID: 17083044). This antibody is capable of neutralizing CK5 strain of rotavirus in an in vitro plaque assay with an IC50 of approximately 3 nM. Daily oral administration of 50 or 100microg 2B10 nanobody could either prevent diarrhea or reduce the number of days with diarrhea per mouse pup model (PMID: 21939690). The mouse IgG1 Fc-fusion version of this antibody confers significantly increased protection against rotavirus in a neonatal mouse model of rotavirus-induced diarrhea by reducing the prevalence, duration and severity of diarrhea and the viral load in the small intestines (PMID: 27439689).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

2B10 (ARP1; VHH1)

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original VHH format for improved compatibility with existing reagents assays and techniques.

Virus

-20°C,2°C to 8°C

12352203