Anti-Rotavirus A capsid glycoprotein VP7 [4F8]

Absolute Antibody

Anti-Rotavirus A capsid glycoprotein VP7 [4F8]

9

This antibody binds the outer capsid glycoprotein VP7 of the Rotavirus A serotype 3. This antibody can bind rhesus and equine strains of Rotaviruses. Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. A rotavirus infection is a

This antibody neutralized serotype 3 rotaviruses RRV and simian rotavirus (SA11) in plaque reduction neutralization assay and protected suckling mice in vivo against serotype 3 (RRV and SA11) but not against OSU or UK virus challenge (Offit et al., 1986; PMID: 2422398). This antibody was used to detect rotaviruses from stools of infants with gastroenteritis using ELISA (Padilla-Noriega et al., 1990; PMID: 2166073). The crystal structure of the Fab fragment of the antibody in complex with rhesus rotavirus (RRV, serotype G3) VP7 trimer was determined. The Fab fragment showed a stronger neutralization activity against RRV than the original format (Aoki et al., 2009; PMID: 19520960).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

4F8

Rabbit

IgG

Virus

-20°C,2°C to 8°C

12352203