Anti-RSPO2 [h130M23-H1L2]

Absolute Antibody

Anti-RSPO2 [h130M23-H1L2]

9

The antibody specifically reacts with human and mouse RSPO2.

The antibody was shown to completely block beta-catenin signaling, demonstrating it is a specific inhibitor of RSPO2. The antibody blocked soluble RSPO2 binding to LGR5. The antibody had a binding affinity for human RSPO2 of 0.14 nM and mouse RSPO2 of 0.35 nM. The antibody demonstrated strong anti-tumor growth activity in combination with gemcitabine in a pancreatic xenograft model and inhibition of pancreatic tumor growth in vivo as a single agent and in combination with additional therapeutic agents. The humanized version of the antibody was produced. The humanized version had a binding affinity for human RSPO2 of 0.13 nM (US8802097B2).

Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

h130M23-H1L2

RSPO2

R-spondin 2

CRISTIN2; HHRRD; roof plate-specific spondin-2; R-spondin 2 homolog; R-spondin-2; TETAMS2

Mouse

IgG1

R-spondin-2

Human, Mouse

-20°C,2°C to 8°C

12352203