Anti-RSV [RSHZ19 (Felvizumab)]

Absolute Antibody

Anti-RSV [RSHZ19 (Felvizumab)]

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This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.

Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).

Functional Assay, ELISA

functional; ELISA

Research Use Only

Monoclonal

RSHZ19 (Felvizumab)

Human

IgG1

Virus

RSV

This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.

-20°C,2°C to 8°C

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