Anti-S protein (RBD) [1E2]

Absolute Antibody

Anti-S protein (RBD) [1E2]

9

The antibody binds to the RBD of the Spike protein of SARS-CoV.

The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the VHH fragment to SARS-CoV-2 RBD was measured by surface plasmon resonance (Kd= 35.5 nM). The VHH showed half maximal neutralization concentration (EC50) of 0.069 microg/mL and 0.2401 microg/mL against SARS-CoV-2 pseudotypes, and authentic SARS-CoV-2, respectively. Fusion of the human IgG1 Fc to the VHH improved the neutralizing activity compared to the original format of the antibody. The Fc-fused VHH demonstrated potency with EC50 of 0.538 nM. (Chi et al, 2020; pmid: 32913273)

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

1E2

S

surface glycoprotein

GU280_gp02; spike glycoprotein; surface glycoprotein

Rabbit

IgG

Spike glycoprotein

Virus

-20°C,2°C to 8°C

12352203