Anti-SARS-CoV S glycoprotein [11A]

Absolute Antibody

Anti-SARS-CoV S glycoprotein [11A]

9

This antibody specifically binds the amino acids 472 and 480 in the S1 domain of the SARS-CoV Spike protein (GD03).

This antibody inhibits the association of SARS-CoV S protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus strain GD03. 11A potently inhibited GD03-RBDs binding to ACE2 expressing 293T cells. Kinetic analysis of 11A IgG binding to GD03-RBD demonstrated high affinity interaction (KD = 2.260.7 nM). Single amino acid changes at either position D480A or D480G resulted in complete loss of 11A binding. (Sui et al., 2008)

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

11A

Human

IgG1

Spike glycoprotein

Virus

-20°C,2°C to 8°C

12352203