Anti-SARS-CoV S glycoprotein [11A]

Absolute Antibody

Anti-SARS-CoV S glycoprotein [11A]

9

This antibody specifically binds the amino acids 472 and 480 in the S1 domain of the SARS-CoV Spike protein (GD03).

This antibody inhibits the association of SARS-CoV S protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus strain GD03. 11A potently inhibited GD03-RBDs binding to ACE2 expressing 293T cells. Kinetic analysis of 11A IgG binding to GD03-RBD demonstrated high affinity interaction (KD = 2.260.7 nM). Single amino acid changes at either position D480A or D480G resulted in complete loss of 11A binding. (Sui et al., 2008)

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

11A

Human

IgM

Spike glycoprotein

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203