Anti-SARS-CoV S glycoprotein [256]

Absolute Antibody

Anti-SARS-CoV S glycoprotein [256]

9

This antibody specifically binds the amino acids 472 and 480 in the S1 domain of the SARS-CoV Spike protein (Tor2 and GD03).

This antibody inhibits the association of SARS-CoV S protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus. 256-IgG1 was capable of neutralizing both the mutations of the spike protein at D480A and D480G. It also neutralized Tor2 and marginally neutralized GD03. Neither of the antibodies 11A nor 80R competed with 256 IgG1 for binding to Tor2 suggesting that the binding epitope of 256 was different from that of 80R and 11A (Sui et. al, 2008)

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

256

Human

IgM

Spike glycoprotein

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203