Anti-SARS-CoV S glycoprotein [4G2]

Absolute Antibody

Anti-SARS-CoV S glycoprotein [4G2]

9

This antibody specifically binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein (Urbani strain).

This antibody inhibits the association of SARS-CoV s protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus.The originally characterized antibody had a neutralizing titer 200TCID50 of 0.781microg/ml (Coughlin et at. 2006) and IC50 of 4.78microg/ml when incubated with S12-510- Fc recombinant protein (Coughlin et at. 2009). This antibody can also mildly bind the Sin845, GD01 and GZ0402 mutants of the Urbani 12-510 S1 sequence. (Elshabrawy et al. 2012). Other applications include ELISA.

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

4G2

Human

IgM

Spike glycoprotein

This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203