Anti-SARS-CoV S glycoprotein [6B1]

Absolute Antibody

Anti-SARS-CoV S glycoprotein [6B1]

9

This antibody specifically binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein (Urbani strain).

This antibody inhibits the association of SARS-CoV s protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus. The originally characterized antibody had has a neutralizing titer 200TCID50 of 3.125 microg/ml (Coughlin et at.,2006) and IC50 of 4.08microg/ml when incubated with S12-510- Fc recombinant protein (Coughlin et at.,2009). This antibody 6B1 showed about 50% binding to Sin845 S1 protein relative to their binding to Urbani S1 protein. GZ0402-S1 protein showed minimal of 52% binding to HmAbs 6B1 (Elshabrawy et al., 2012). Other applications include ELISA.

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

6B1

Mouse

IgG2b

Spike glycoprotein

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203